Intratumor Diversity and Clonal Evolution in Cancer

Original Article. Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. Marco Gerlinger, M.D., Andrew J. Rowan, B.Sc., Stuart …
The authors analyze the extent of intratumor heterogeneity across 12 tumor types to reveal that increased heterogeneity is a general phenomenon and has a biphasic ...
Sequencing studies of breast tumor cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumors.
Models of Heterogeneity. There are two models used to explain the heterogeneity of tumour cells. These are the cancer stem cell model and the clonal evolution model.
Genetic analyses have shaped much of our understanding of cancer. However, it is becoming increasingly clear that cancer cells display features of normal tissue ...

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